NME3

Across TCGA patient cohorts, NME3 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible NME3-associated genes across cancer lineages are ACTRT1, LACRT, and CHEK2P5. Each is linked with NME3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NME3-to-partner and partner-to-NME3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTRT1 grouped by NME3-low versus NME3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NME3→partner) and Y-score (partner→NME3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ACTRT1 →	+0.033	+5.159	.001	.007	3	1
SKCM	LACRT →	+0.063	+5.771	<.001	.003	3	1
SKCM	CHEK2P5 →	+0.302	+6.199	<.001	.001	3	1
SKCM	LINC01221 →	+0.072	+5.224	.001	.007	3	1
SKCM	PCNPP4 →	+0.092	+5.037	<.001	.009	3	1
SKCM	BTBD7P2 →	+0.122	+5.594	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ACTRT1 by NME3 expression — SKCM

Explore this box plot interactively →