NME1-NME2

Across TCGA patient cohorts, NME1-NME2 mutation is significantly associated with the RNA expression of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NME1-NME2-associated genes across cancer lineages are RNU6-434P, MIR6842, and RNA5SP534. Each is linked with NME1-NME2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NME1-NME2-to-partner and partner-to-NME1-NME2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-434P grouped by NME1-NME2-low versus NME1-NME2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NME1-NME2→partner) and Y-score (partner→NME1-NME2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-434P →	+0.569	+3.453	.002	.009	3	2
UCEC	MIR6842 →	+0.530	+4.722	<.001	.004	3	1
UCEC	RNA5SP534 →	+0.797	+4.242	<.001	.002	3	1
UCEC	SPATA31A7 →	+0.010	+4.226	<.001	.008	3	1
UCEC	MIR548AR →	+1.219	+3.600	.002	.009	3	1
UCEC	RN7SL45P →	+0.492	+3.735	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

RNU6-434P by NME1-NME2 expression — UCEC

Explore this box plot interactively →