NME1-NME2

Across TCGA pan-cancer cohorts, NME1-NME2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NME1-NME2 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher NME1-NME2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NME1-NME2 expression acts as an unfavorable survival marker, although some lineages such as LGG and GBM show a favorable association.

BLCA, KIRC, and MESO are the cancer types where NME1-NME2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	II,III,IV	0.628	0.774	.001	96	view →
KIRC	DFS	Median	All	0.829	0.912	<.001	76	view →
MESO	DFS	Median	All	0.272	0.453	.001	70	view →
PAAD	OS	Tertile	All	0.445	0.715	<.001	66	view →
KICH	OS	Median	All	0.822	1.000	.007	49	view →
UVM	DFS	Tertile	All	0.470	0.813	.001	49	view →
ACC	DFS	Median	All	0.413	0.736	<.001	30	view →
LIHC	DFS	Quartile	All	0.306	0.532	<.001	30	view →
LGG	OS	Quartile	All	0.945	0.825	<.001	28	view →
SARC	OS	Median	All	0.414	0.598	.004	26	view →
GBM	OS	Median	All	0.328	0.211	.003	24	view →
SCLC	DFS	Tertile	III,IV	0.660	0.301	.007	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NME1-NME2–BLCA (OS)

Open the BLCA breakdown →