NME1-NME2

Across TCGA pan-cancer cohorts, NME1-NME2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NME1-NME2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NME1-NME2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NME1-NME2 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, KIRP, and LUAD are the cancer types where NME1-NME2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NME1-NME2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.291	<.001	11	view →
KIRP	All	III,IV	+1.287	<.001	11	view →
LUAD	Male	All	+0.625	<.001	11	view →
KIRC	All	IV	+0.520	<.001	11	view →
LUSC	Male	II,III,IV	+1.268	<.001	8	view →
HNSC	Male	All	+0.686	<.001	8	view →
BRCA	All	All	+0.496	<.001	8	view →
STAD	All	All	+0.409	<.001	8	view →
BLCA	Male	All	+1.176	<.001	7	view →
LIHC	Male	All	+0.457	<.001	6	view →
READ	All	All	+0.700	.011	2	view →
PRAD	All	All	+0.556	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NME1-NME2–COAD

Open the COAD breakdown →