NKX6-3

Across TCGA patient cohorts, NKX6-3 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKX6-3-associated genes across cancer lineages are MIR6854, SNRPGP17, and MIR7976. Each is linked with NKX6-3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX6-3-to-partner and partner-to-NKX6-3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6854 grouped by NKX6-3-low versus NKX6-3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX6-3→partner) and Y-score (partner→NKX6-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6854 →	+0.453	+4.997	<.001	.003	3	1
UCEC	SNRPGP17 →	+0.430	+3.879	.004	.008	3	1
UCEC	MIR7976 →	+0.676	+4.038	.001	.004	3	1
UCEC	ARPP19P2 →	+0.317	+4.354	.007	.002	3	1
UCEC	RNU6-1228P →	+0.327	+5.464	<.001	.001	3	1
UCEC	CYCSP19 →	+0.324	+4.454	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

MIR6854 by NKX6-3 expression — UCEC

Explore this box plot interactively →