NKX6-3

Across TCGA pan-cancer cohorts, NKX6-3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NKX6-3 data layer compared with 1 for mutation status.

The strongest signal is observed in brain lower grade glioma (LGG), where higher NKX6-3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated NKX6-3 expression acts as an unfavorable survival marker, although some lineages such as LGG and ESCA show a favorable association.

LGG, UVM, and ESCA are the cancer types where NKX6-3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.564	0.309	<.001	53	view →
UVM	OS	Tertile	II,III,IV	0.614	0.883	.001	48	view →
ESCA	DFS	Quartile	II,III,IV	0.654	0.285	<.001	41	view →
COAD	OS	Tertile	IV	0.433	0.771	.003	33	view →
ACC	DFS	Tertile	III,IV	0.046	0.670	.001	30	view →
STAD	DFS	Median	IV	0.109	0.681	<.001	30	view →
SCLC	DFS	Median	All	0.399	0.150	.008	30	view →
THYM	DFS	Median	II,III,IV	0.923	0.753	.007	26	view →
KIRC	OS	Tertile	All	0.555	0.677	.009	20	view →
SKCM	DFS	Quartile	All	0.722	0.594	.002	17	view →
PAAD	OS	Quartile	II,III,IV	0.697	0.415	.020	15	view →
SARC	DFS	Quartile	All	0.732	0.571	.013	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NKX6-3–LGG (DFS)

Open the LGG breakdown →