NKX6-3

Across TCGA pan-cancer cohorts, NKX6-3 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of NKX6-3’s most consistent transcriptional readouts.

The strongest signal is observed in rectum adenocarcinoma (READ), where NKX6-3 RNA is repressed in tumor relative to normal tissue. In most cancer types NKX6-3 is over-expressed in tumor, although a few such as READ show the opposite, repressed pattern.

READ, LUAD, and UCEC are the cancer types where NKX6-3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NKX6-3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
READ	All	All	−0.130	.006	3	view →
LUAD	Male	All	+0.059	.008	3	view →
UCEC	All	All	+0.573	.038	2	view →
LUSC	All	All	+0.314	.010	2	view →
PRAD	All	All	+0.038	.017	2	view →
KIRC	Male	All	+0.011	.015	2	view →
STAD	Male	II,III,IV	+1.625	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

NKX6-3–READ

Open the READ breakdown →