NKX6-1

Across TCGA patient cohorts, NKX6-1 mutation is significantly associated with the RNA expression of many other genes, with 529 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKX6-1-associated genes across cancer lineages are COPS8P3, PDLIM1P3, and MIR6752. Each is linked with NKX6-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX6-1-to-partner and partner-to-NKX6-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPS8P3 grouped by NKX6-1-low versus NKX6-1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX6-1→partner) and Y-score (partner→NKX6-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COPS8P3 →	+0.152	+2.846	<.001	.002	3	2
HNSC	PDLIM1P3 →	+0.100	+5.069	<.001	.008	3	2
READ	MIR6752 →	+0.813	+4.421	<.001	.009	3	2
HNSC	RNU6-1217P →	+0.364	+5.015	<.001	.009	3	1
UCEC	INTS4 →	+0.396	+3.617	.007	.001	3	1
UCEC	LAMTOR1 →	+0.401	+3.595	.009	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 529 associations by consensus.

COPS8P3 by NKX6-1 expression — UCEC

Explore this box plot interactively →