NKX6-1

Across TCGA pan-cancer cohorts, NKX6-1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NKX6-1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NKX6-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NKX6-1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, THCA, and BRCA are the cancer types where NKX6-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NKX6-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.781	<.001	11	view →
THCA	Male	All	−1.675	<.001	8	view →
BRCA	All	III,IV	+0.896	<.001	6	view →
LUSC	All	II,III,IV	+0.706	<.001	6	view →
KICH	Male	All	+3.397	<.001	5	view →
LUAD	Female	All	+0.322	<.001	5	view →
KIRC	All	All	−0.032	.016	4	view →
UCEC	All	All	+0.639	.010	2	view →
PRAD	All	All	+0.480	<.001	2	view →
LIHC	Female	All	+0.007	.038	2	view →
STAD	Female	III,IV	−0.420	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

NKX6-1–HNSC

Open the HNSC breakdown →