NKX6-1

Across TCGA pan-cancer cohorts, NKX6-1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated NKX6-1 data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher NKX6-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NKX6-1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and BRCA show a favorable association.

UVM, KIRC, and KIRP are the cancer types where NKX6-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	II,III,IV	0.402	0.832	<.001	154	view →
KIRC	DFS	Quartile	III,IV	0.302	0.515	.001	114	view →
KIRP	DFS	Median	All	0.778	0.938	<.001	64	view →
SCLC	DFS	Median	II,III,IV	0.780	0.403	.001	51	view →
LGG	OS	Tertile	All	0.387	0.658	<.001	39	view →
BRCA	OS	Median	IV	0.992	0.501	<.001	32	view →
MESO	OS	Median	III,IV	0.298	0.525	.004	22	view →
PAAD	DFS	Tertile	All	0.411	0.188	.008	22	view →
ACC	DFS	Tertile	All	0.466	0.837	.012	20	view →
PRAD	DFS	Quartile	All	0.677	0.865	.005	18	view →
SARC	OS	Median	All	0.656	0.825	<.001	16	view →
LUAD	DFS	Median	II,III,IV	0.610	0.419	.039	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

NKX6-1–UVM (OS)

Open the UVM breakdown →