NKX2-8

Across TCGA patient cohorts, NKX2-8 mutation is significantly associated with the RNA expression of many other genes, with 395 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKX2-8-associated genes across cancer lineages are RNU1-83P, TMSB4Y, and PI4K2A. Each is linked with NKX2-8 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-8-to-partner and partner-to-NKX2-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-83P grouped by NKX2-8-low versus NKX2-8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-8→partner) and Y-score (partner→NKX2-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU1-83P →	+0.433	+3.626	<.001	<.001	3	2
UCEC	TMSB4Y →	+0.111	+4.200	.006	<.001	3	1
UCEC	PI4K2A →	+0.444	+3.210	.005	.009	3	1
UCEC	DBF4B →	+0.636	+3.235	.002	.009	3	1
UCEC	SSTR5 →	+0.822	+3.091	<.001	.001	3	1
UCEC	C1orf50 →	+0.495	+3.364	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 395 associations by consensus.

RNU1-83P by NKX2-8 expression — UCEC

Explore this box plot interactively →