NKX2-8

Across TCGA pan-cancer cohorts, NKX2-8 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NKX2-8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where NKX2-8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NKX2-8 is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.

KIRP, KIRC, and BRCA are the cancer types where NKX2-8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NKX2-8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+0.780	.008	8	view →
KIRC	All	All	+0.104	.007	8	view →
BRCA	All	IV	−0.209	.005	6	view →
BLCA	All	All	+1.211	.001	5	view →
LUAD	Male	All	−0.975	<.001	5	view →
UCEC	All	All	+0.475	.008	4	view →
KICH	All	II,III,IV	−0.093	.009	4	view →
LUSC	All	III,IV	−1.325	.001	2	view →
COAD	All	All	+0.170	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

NKX2-8–KIRP

Open the KIRP breakdown →