NKX2-8

Across TCGA pan-cancer cohorts, NKX2-8 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NKX2-8 data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NKX2-8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NKX2-8 expression acts as an unfavorable survival marker, although some lineages such as READ and LUAD show a favorable association.

HNSC, KIRC, and STAD are the cancer types where NKX2-8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.647	0.742	<.001	128	view →
KIRC	DFS	Tertile	All	0.522	0.665	<.001	122	view →
STAD	OS	Quartile	III,IV	0.334	0.559	.001	78	view →
READ	DFS	Tertile	III,IV	0.877	0.271	.007	56	view →
UVM	DFS	Median	III,IV	0.192	0.897	<.001	50	view →
UCEC	DFS	Quartile	All	0.749	0.854	.007	44	view →
KIRP	DFS	Quartile	All	0.535	0.755	<.001	38	view →
SKCM	OS	Median	All	0.257	0.402	<.001	38	view →
LIHC	OS	Tertile	II,III,IV	0.326	0.653	.011	27	view →
LUAD	OS	Median	II,III,IV	0.537	0.336	.008	25	view →
ESCA	OS	Tertile	III,IV	0.402	0.657	.013	21	view →
COAD	DFS	Tertile	All	0.360	0.560	.016	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NKX2-8–HNSC (DFS)

Open the HNSC breakdown →