NKX2-6

Across TCGA patient cohorts, NKX2-6 mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKX2-6-associated genes across cancer lineages are SMR3A, IL21, and DEFB106A. Each is linked with NKX2-6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-6-to-partner and partner-to-NKX2-6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMR3A grouped by NKX2-6-low versus NKX2-6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-6→partner) and Y-score (partner→NKX2-6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMR3A →	+0.787	+3.934	.005	.002	3	1
UCEC	IL21 →	+0.182	+3.611	.001	.001	3	1
BRCA	DEFB106A →	+0.154	+8.471	<.001	.005	3	1
BRCA	MIR4287 →	+0.431	+7.731	<.001	.009	3	1
ESCA	MIR448 →	+0.207	+4.450	.009	.009	3	1
ESCA	DAZ4 →	+0.177	+4.311	.006	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

SMR3A by NKX2-6 expression — UCEC

Explore this box plot interactively →