NKX2-6

Across TCGA pan-cancer cohorts, NKX2-6 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated NKX2-6 data layer compared with 1 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher NKX2-6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NKX2-6 expression acts as an unfavorable survival marker, although some lineages such as STAD and PRAD show a favorable association.

KICH, LUAD, and LIHC are the cancer types where NKX2-6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.081	0.904	<.001	90	view →
LUAD	DFS	Tertile	All	0.421	0.681	<.001	45	view →
LIHC	OS	Tertile	All	0.253	0.778	<.001	45	view →
ACC	DFS	Tertile	III,IV	0.326	0.722	.006	45	view →
READ	DFS	Tertile	All	0.570	0.827	.013	33	view →
KIRC	DFS	Tertile	All	0.661	0.817	.014	30	view →
OV	DFS	Tertile	IV	0.220	0.471	.025	18	view →
PAAD	OS	Tertile	III,IV	0.558	0.924	.014	15	view →
LGG	DFS	Tertile	All	0.170	0.461	.006	9	view →
STAD	OS	Tertile	IV	0.682	0.258	.040	9	view →
PRAD	DFS	Tertile	All	0.905	0.682	.006	8	view →
SKCM	OS	Median	III,IV	0.689	0.277	.012	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

NKX2-6–KICH (DFS)

Open the KICH breakdown →