NKX2-6

Across TCGA pan-cancer cohorts, NKX2-6 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of NKX2-6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NKX2-6 RNA is repressed in tumor relative to normal tissue. In most cancer types NKX2-6 is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

HNSC, LUSC, and KICH are the cancer types where NKX2-6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NKX2-6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	−0.133	.027	2	view →
LUSC	Female	All	+0.119	.040	2	view →
KICH	All	II,III,IV	−0.032	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

NKX2-6–HNSC

Open the HNSC breakdown →