Across TCGA patient cohorts, NKX2-5 protein abundance is significantly associated with the RNA expression of many other genes, with 848 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible NKX2-5-associated genes across cancer lineages are EXOSC3P1, STRIP1, and CARD10. Each is linked with NKX2-5 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-5-to-partner and partner-to-NKX2-5 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-5→partner) and Y-score (partner→NKX2-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EXOSC3P1 →	+1.488	+1.114	.004	.007	2	2
HNSC	STRIP1 →	-0.817	-1.035	.002	.008	2	2
HNSC	CARD10 →	-1.729	-1.032	<.001	.001	3	1
HNSC	TTC28 →	+0.995	+1.004	.002	.007	3	1
HNSC	PYGL →	-1.645	-1.449	.002	<.001	3	1
HNSC	ATP6V1D →	-0.819	-1.112	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 848 associations by consensus.

Exploration

NKX2-5 survival (RNA) · tumor vs normal (RNA) · all NKX2-5 data types