Across TCGA pan-cancer cohorts, NKX2-5 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated NKX2-5 data layer compared with 6 for mutation status and 1 for mass-spec protein.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NKX2-5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NKX2-5 expression acts as an unfavorable survival marker, although some lineages such as KIRP and READ show a favorable association.
KIRC, MESO, and THCA are the cancer types where NKX2-5 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.