Across TCGA pan-cancer cohorts, NKX2-5 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NKX2-5’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where NKX2-5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NKX2-5 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
LUSC, HNSC, and THCA are the cancer types where NKX2-5 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NKX2-5 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.