NKX2-4

Across TCGA patient cohorts, NKX2-4 protein abundance is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKX2-4-associated genes across cancer lineages are GABRA3, ALDH1A1, and PROKR1. Each is linked with NKX2-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-4-to-partner and partner-to-NKX2-4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NKX2-4 versus GABRA3 in UCEC, with a Pearson correlation of 0.89.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-4→partner) and Y-score (partner→NKX2-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GABRA3 →	+1.305	+0.175	.002	<.001	2	1
UCEC	ALDH1A1 →	+2.550	+0.175	.004	<.001	2	1
UCEC	PROKR1 →	+0.324	+0.175	.003	<.001	2	1
UCEC	LRRC3B →	+1.175	+0.175	.007	<.001	2	1
UCEC	SLC34A3 →	+1.155	+0.175	.002	<.001	2	1
UCEC	TPT1P13 →	+1.665	+0.175	.005	<.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

NKX2-4 vs GABRA3 — UCEC

Explore this scatter interactively →