NKX2-4

Across TCGA pan-cancer cohorts, NKX2-4 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated NKX2-4 data layer compared with 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NKX2-4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated NKX2-4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRP show a favorable association.

HNSC, KIRP, and STAD are the cancer types where NKX2-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.831	0.721	.009	49	view →
KIRP	DFS	Quartile	II,III,IV	1.000	0.584	.004	42	view →
STAD	OS	Tertile	II,III,IV	0.428	0.677	.001	38	view →
SKCM	OS	Quartile	All	0.222	0.416	<.001	36	view →
UVM	DFS	Quartile	III,IV	0.490	1.000	.002	29	view →
UCS	OS	Tertile	IV	0.224	0.682	.010	24	view →
GBM	DFS	Median	All	0.262	0.167	.016	18	view →
MESO	DFS	Tertile	IV	0.079	0.414	.004	18	view →
SARC	OS	Tertile	All	0.530	0.787	<.001	18	view →
READ	OS	Tertile	II,III,IV	0.672	0.931	.005	18	view →
BLCA	OS	Tertile	All	0.223	0.464	.035	6	view →
UCEC	DFS	Tertile	All	0.844	0.904	.039	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

NKX2-4–HNSC (OS)

Open the HNSC breakdown →