NKX2-4

Across TCGA pan-cancer cohorts, NKX2-4 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of NKX2-4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where NKX2-4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NKX2-4 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRP, THCA, and LUSC are the cancer types where NKX2-4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NKX2-4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	All	+0.589	.011	3	view →
THCA	All	All	−0.013	.001	2	view →
LUSC	All	All	+0.208	.025	1	view →
LUAD	All	All	+0.130	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

NKX2-4–KIRP

Open the KIRP breakdown →