NKX2-3

Across TCGA cell cohorts, NKX2-3 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. CNS shows the largest number of these associations.

The most reproducible NKX2-3-associated genes across cancer lineages are OR11H6 and VN1R4. Each is linked with NKX2-3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-3-to-partner and partner-to-NKX2-3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H6 grouped by NKX2-3-low versus NKX2-3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-3→partner) and Y-score (partner→NKX2-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR11H6 →	+0.025	+5.321	<.001	.005	3	1
CNS	VN1R4 →	+0.098	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

OR11H6 by NKX2-3 expression — CNS

Explore this box plot interactively →