NKX2-3

Across TCGA pan-cancer cohorts, NKX2-3 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated NKX2-3 data layer compared with 1 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher NKX2-3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NKX2-3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

BRCA, HNSC, and KIRP are the cancer types where NKX2-3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.517	0.625	<.001	124	view →
HNSC	DFS	Tertile	IV	0.766	0.533	<.001	121	view →
KIRP	DFS	Tertile	All	0.565	0.769	<.001	92	view →
ACC	OS	Tertile	All	0.731	0.946	<.001	70	view →
LAML	DFS	Quartile	All	0.187	0.623	.002	36	view →
UCS	DFS	Tertile	II,III,IV	0.546	0.133	.009	30	view →
THYM	OS	Quartile	All	0.860	1.000	.007	28	view →
LUSC	DFS	Median	II,III,IV	0.777	0.652	.009	27	view →
UVM	OS	Median	III,IV	0.252	0.836	.005	24	view →
SCLC	OS	Tertile	IV	0.959	0.274	.013	19	view →
SKCM	OS	Tertile	IV	0.475	0.783	<.001	18	view →
LIHC	DFS	Median	All	0.612	0.483	.003	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

NKX2-3–BRCA (OS)

Open the BRCA breakdown →