NKX2-3

Across TCGA pan-cancer cohorts, NKX2-3 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NKX2-3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NKX2-3 RNA is repressed in tumor relative to normal tissue. In most cancer types NKX2-3 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and READ are the cancer types where NKX2-3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NKX2-3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−2.342	<.001	12	view →
HNSC	Female	III,IV	−2.253	<.001	10	view →
READ	Female	All	−2.692	<.001	5	view →
LUSC	All	II,III,IV	+0.552	<.001	5	view →
THCA	All	III,IV	−0.582	.004	4	view →
KIRC	All	All	+0.229	.005	4	view →
BRCA	Female	All	+0.158	.005	4	view →
PRAD	All	All	+1.385	<.001	2	view →
LIHC	All	All	+0.100	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

NKX2-3–COAD

Open the COAD breakdown →