NKX2-1

Across TCGA patient cohorts, NKX2-1 RNA expression is significantly associated with the RNA expression of many other genes, with 10,136 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible NKX2-1-associated genes across cancer lineages are NKX2-1-AS1, SFTA3, and NKX2-8. Each is linked with NKX2-1 in more than 28 cancer types. Because this analysis shows association rather than direction, both NKX2-1-to-partner and partner-to-NKX2-1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NKX2-1 versus NKX2-1-AS1 in LUAD, with a Pearson correlation of 0.89.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-1→partner) and Y-score (partner→NKX2-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NKX2-1-AS1 →	+1.827	+2.009	<.001	<.001	3	29
LUSC	SFTA3 →	+2.965	+3.075	<.001	<.001	3	28
ESCA	NKX2-8 →	+1.442	+0.426	<.001	<.001	3	21
LUAD	PTCSC3 →	+1.569	+1.785	<.001	<.001	3	17
LUAD	MBIP →	+1.401	+2.062	<.001	<.001	3	15
SCLC	DLX6 →	+2.577	+2.679	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,136 associations by consensus.

NKX2-1 vs NKX2-1-AS1 — LUAD

Explore this scatter interactively →