NKX2-1

Across TCGA pan-cancer cohorts, NKX2-1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of NKX2-1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where NKX2-1 RNA is repressed in tumor relative to normal tissue. In most cancer types NKX2-1 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and BLCA are the cancer types where NKX2-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NKX2-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−4.611	<.001	8	view →
LUAD	All	All	−0.724	.002	4	view →
BLCA	All	III,IV	+0.998	.030	3	view →
HNSC	Female	All	+0.222	.025	3	view →
PRAD	All	All	+0.530	.004	2	view →
THCA	Female	All	+0.320	.044	2	view →
COAD	All	All	+0.330	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

NKX2-1–LUSC

Open the LUSC breakdown →