NKX2-1

Across TCGA pan-cancer cohorts, NKX2-1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated NKX2-1 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NKX2-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NKX2-1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and SKCM show a favorable association.

HNSC, LUSC, and KIRC are the cancer types where NKX2-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.628	0.752	.001	82	view →
LUSC	DFS	Quartile	II,III,IV	0.470	0.710	<.001	80	view →
KIRC	OS	Tertile	All	0.489	0.668	<.001	78	view →
MESO	OS	Tertile	IV	0.171	0.726	<.001	75	view →
LUAD	OS	Quartile	All	0.878	0.740	<.001	61	view →
ACC	OS	Tertile	III,IV	0.295	0.878	.004	34	view →
UCEC	OS	Tertile	All	0.892	0.940	.015	28	view →
UVM	OS	Tertile	All	0.629	0.928	.007	27	view →
LGG	DFS	Median	All	0.690	0.784	.006	24	view →
ESCA	DFS	Median	III,IV	0.304	0.526	.009	24	view →
OV	OS	Quartile	All	0.580	0.714	.002	18	view →
COAD	DFS	Quartile	IV	0.205	0.567	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

NKX2-1–HNSC (DFS)

Open the HNSC breakdown →