Q-omics provides the consensus-scored NKX2-1-AS1 profile across patient tissues and cancer cell-line models. NKX2-1-AS1 expression is associated with patient survival in 18 of 34 cancer types, with the highest sampling consensus in LUSC. Among the 18 cancer types available for tumor–normal comparison, NKX2-1-AS1 is differentially expressed in 5, with the highest sampling consensus in LUSC. Additionally, NKX2-1-AS1 RNA expression shows 9,247 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight LUSC, and TGCT as cancer lineages where NKX2-1-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NKX2-1-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NKX2-1-AS1 survival associations across molecular data types. NKX2-1-AS1 RNA expression shows survival associations in the most cancer types (18). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NKX2-1-AS1 RNA expression–survival associations across cancer types. High NKX2-1-AS1 expression shows unfavorable associations in LUSC, KICH, UCEC, STAD and ESCA, but favorable associations in LUAD. The LUSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LUSC as the clearest survival context for NKX2-1-AS1 RNA expression.
This table summarizes NKX2-1-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for NKX2-1-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NKX2-1-AS1 shows lower tumor expression in LUSC and higher tumor expression in BLCA, HNSC, PRAD and COAD. The LUSC box plot shows higher NKX2-1-AS1 RNA expression in normal versus tumor tissue (log2 FC = −2.474, t-test p < 0.001).
This table shows molecular features associated with NKX2-1-AS1 in patient tissues and cancer cell lines. In patient samples, NKX2-1-AS1 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
