NKX2-1-AS1

Across TCGA pan-cancer cohorts, NKX2-1-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated NKX2-1-AS1 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher NKX2-1-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NKX2-1-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LIHC show a favorable association.

LUSC, KICH, and LUAD are the cancer types where NKX2-1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.653	0.823	<.001	71	view →
KICH	OS	Tertile	All	0.082	0.877	<.001	60	view →
LUAD	OS	Tertile	II,III,IV	0.780	0.621	.004	53	view →
UCEC	OS	Tertile	All	0.532	0.706	.015	48	view →
STAD	DFS	Tertile	All	0.552	0.688	.005	27	view →
SKCM	OS	Tertile	IV	0.247	0.752	.004	24	view →
ESCA	OS	Tertile	IV	0.220	0.767	.017	24	view →
KIRC	DFS	Tertile	II,III,IV	0.196	0.509	.034	24	view →
LIHC	DFS	Tertile	II,III,IV	0.805	0.176	.022	18	view →
THYM	DFS	Quartile	III,IV	0.185	0.825	.001	15	view →
KIRP	DFS	Tertile	III,IV	1.000	0.304	.031	12	view →
COAD	DFS	Tertile	IV	0.256	0.532	.003	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

NKX2-1-AS1–LUSC (OS)

Open the LUSC breakdown →