NIT2

Across TCGA patient cohorts, NIT2 mutation is significantly associated with the RNA expression of many other genes, with 1,436 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIT2-associated genes across cancer lineages are RNU6-499P, MTATP6P29, and USP9YP10. Each is linked with NIT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIT2-to-partner and partner-to-NIT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-499P grouped by NIT2-low versus NIT2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIT2→partner) and Y-score (partner→NIT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-499P →	+0.284	+8.471	<.001	.005	3	2
COAD	MTATP6P29 →	+0.603	+5.435	<.001	.005	3	2
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
UCEC	RNA5SP222 →	+0.217	+3.292	<.001	.003	3	2
UCEC	PGAP2 →	+0.502	+2.595	<.001	<.001	3	1
UCEC	INTS4 →	+0.317	+2.617	.007	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,436 associations by consensus.

RNU6-499P by NIT2 expression — BRCA

Explore this box plot interactively →