NHP2

Across TCGA patient cohorts, NHP2 mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NHP2-associated genes across cancer lineages are RNU6-391P, RNY1P7, and CPLX3. Each is linked with NHP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NHP2-to-partner and partner-to-NHP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-391P grouped by NHP2-low versus NHP2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHP2→partner) and Y-score (partner→NHP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-391P →	+0.331	+7.731	<.001	.009	3	2
BRCA	RNY1P7 →	+0.318	+8.055	<.001	.007	3	1
BRCA	CPLX3 →	+0.154	+8.055	<.001	.007	3	1
BRCA	LINC00353 →	+0.059	+8.055	<.001	.007	3	1
UCEC	HYKK →	+0.457	+3.332	.003	.005	3	1
UCEC	C3orf62 →	+0.429	+3.354	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

RNU6-391P by NHP2 expression — BRCA

Explore this box plot interactively →