NHP2

Across TCGA pan-cancer cohorts, NHP2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated NHP2 data layer compared with 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NHP2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NHP2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

UCEC, UVM, and KIRP are the cancer types where NHP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.784	0.888	<.001	80	view →
UVM	OS	Median	All	0.394	0.822	<.001	79	view →
KIRP	DFS	Median	All	0.841	0.968	<.001	70	view →
LIHC	OS	Median	All	0.608	0.766	<.001	59	view →
KICH	OS	Median	All	0.748	1.000	.001	53	view →
HNSC	DFS	Tertile	II,III,IV	0.502	0.665	.001	51	view →
KIRC	DFS	Tertile	All	0.721	0.530	.001	33	view →
LUAD	OS	Tertile	III,IV	0.386	0.669	.003	27	view →
LAML	DFS	Tertile	All	0.351	0.606	.001	26	view →
READ	DFS	Tertile	All	0.929	0.773	.014	23	view →
SKCM	OS	Quartile	All	0.194	0.490	.008	21	view →
SCLC	DFS	Median	II,III,IV	0.778	0.245	.004	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

NHP2–UCEC (DFS)

Open the UCEC breakdown →