long intergenic non-protein coding RNA 353Genealiases: []
Q-omics provides the consensus-scored LINC00353 profile across patient tissues and cancer cell-line models. LINC00353 expression is associated with patient survival in 12 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, LINC00353 is differentially expressed in 2, with the highest sampling consensus in KICH. Additionally, LINC00353 RNA expression shows 6,199 significant gene co-expression associations, with the highest sampling consensus in COAD. Together, these results highlight BLCA, KICH, and COAD as cancer lineages where LINC00353 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LINC00353 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LINC00353 survival associations across molecular data types. LINC00353 RNA expression shows survival associations in the most cancer types (12). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LINC00353 RNA expression–survival associations across cancer types. High LINC00353 expression shows unfavorable associations in BLCA, CHOL, LIHC, SKCM, LGG and TGCT. The BLCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify BLCA as the clearest survival context for LINC00353 RNA expression.
This table summarizes LINC00353 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for LINC00353. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LINC00353 shows lower tumor expression in KICH and higher tumor expression in HNSC. The KICH box plot shows higher LINC00353 RNA expression in normal versus tumor tissue (log2 FC = −0.028, t-test p = .023).
This table shows molecular features associated with LINC00353 in patient tissues and cancer cell lines. In patient samples, LINC00353 shows the broadest associations at the RNA and protein expression levels, with COAD recurring as the lineage with the largest associated feature set.
