Q-omics provides the consensus-scored NFIA-AS2 profile across patient tissues and cancer cell-line models. NFIA-AS2 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in LUSC. Among the 18 cancer types available for tumor–normal comparison, NFIA-AS2 is differentially expressed in 8, with the highest sampling consensus in THCA. Additionally, NFIA-AS2 RNA expression shows 12,949 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight LUSC, THCA, and TGCT as cancer lineages where NFIA-AS2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NFIA-AS2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NFIA-AS2 survival associations across molecular data types. NFIA-AS2 RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NFIA-AS2 RNA expression–survival associations across cancer types. High NFIA-AS2 expression shows unfavorable associations in LUSC, BLCA, KICH, LAML and LUAD, but favorable associations in UCS. The LUSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LUSC as the clearest survival context for NFIA-AS2 RNA expression.
This table summarizes NFIA-AS2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for NFIA-AS2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NFIA-AS2 shows lower tumor expression in THCA, BRCA, LUSC, UCEC and HNSC and higher tumor expression in KIRC. The THCA box plot shows higher NFIA-AS2 RNA expression in normal versus tumor tissue (log2 FC = −0.708, t-test p < 0.001).
This table shows molecular features associated with NFIA-AS2 in patient tissues and cancer cell lines. In patient samples, NFIA-AS2 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
