NFIA-AS2

Across TCGA pan-cancer cohorts, NFIA-AS2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of NFIA-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NFIA-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types NFIA-AS2 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, KIRC, and BRCA are the cancer types where NFIA-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NFIA-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.708	<.001	11	view →
KIRC	All	All	+0.139	<.001	9	view →
BRCA	All	III,IV	−0.426	<.001	6	view →
LUSC	All	All	−0.309	<.001	6	view →
UCEC	All	III,IV	−0.296	.023	6	view →
HNSC	Male	All	−0.281	.006	3	view →
CHOL	All	All	+0.552	.008	2	view →
LIHC	All	All	+0.052	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

NFIA-AS2–THCA

Open the THCA breakdown →