NFIA-AS2

Across TCGA pan-cancer cohorts, NFIA-AS2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NFIA-AS2 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher NFIA-AS2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NFIA-AS2 expression acts as an unfavorable survival marker, although some lineages such as UCS and PAAD show a favorable association.

LUSC, BLCA, and KICH are the cancer types where NFIA-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.305	0.474	<.001	63	view →
BLCA	OS	Median	All	0.340	0.508	<.001	60	view →
KICH	DFS	Quartile	III,IV	0.221	1.000	.003	43	view →
UCS	OS	Quartile	II,III,IV	0.787	0.322	.002	38	view →
LAML	DFS	Tertile	All	0.166	0.508	.007	36	view →
LUAD	DFS	Median	IV	0.270	0.807	.003	30	view →
LGG	DFS	Quartile	All	0.407	0.600	.001	26	view →
PAAD	OS	Tertile	II,III,IV	0.712	0.504	.006	25	view →
KIRC	DFS	Quartile	All	0.524	0.714	.006	23	view →
LIHC	DFS	Tertile	All	0.241	0.346	.008	17	view →
READ	OS	Quartile	III,IV	0.389	0.933	.007	15	view →
BRCA	OS	Median	III,IV	0.679	0.386	.005	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NFIA-AS2–LUSC (DFS)

Open the LUSC breakdown →