NECTIN4

Across TCGA cell cohorts, NECTIN4 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NECTIN4-associated genes across cancer lineages are OR4X2, KLK12, and IFNA14. Each is linked with NECTIN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NECTIN4-to-partner and partner-to-NECTIN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by NECTIN4-low versus NECTIN4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NECTIN4→partner) and Y-score (partner→NECTIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR4X2 →	+0.032	+5.369	<.001	.004	3	1
SOFT_TISSUE	KLK12 →	+1.031	+4.930	<.001	.008	3	1
SOFT_TISSUE	IFNA14 →	+0.028	+5.369	<.001	.004	3	1
SKIN	MAS1 →	+0.619	+4.977	<.001	.007	3	1
SKIN	SLC22A8 →	+0.026	+5.415	<.001	.004	3	1
SKIN	MRGPRX2 →	+0.006	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

OR4X2 by NECTIN4 expression — SOFT_TISSUE

Explore this box plot interactively →