NDUFAF4

Across TCGA patient cohorts, NDUFAF4 mutation is significantly associated with the RNA expression of many other genes, with 197 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDUFAF4-associated genes across cancer lineages are RNU4-27P, MTND3P13, and ZNF736P7Y. Each is linked with NDUFAF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDUFAF4-to-partner and partner-to-NDUFAF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-27P grouped by NDUFAF4-low versus NDUFAF4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDUFAF4→partner) and Y-score (partner→NDUFAF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU4-27P →	+0.296	+4.625	<.001	<.001	3	2
COAD	MTND3P13 →	+0.148	+4.308	<.001	.009	3	2
COAD	ZNF736P7Y →	+0.068	+4.666	<.001	.005	3	2
UCEC	SKA3 →	+0.896	+3.234	.002	.009	3	1
UCEC	PIGG →	+0.578	+3.202	.001	.009	3	1
UCEC	FAM136A →	+0.726	+3.235	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 197 associations by consensus.

RNU4-27P by NDUFAF4 expression — LUSC

Explore this box plot interactively →