NDUFAF4

Across TCGA pan-cancer cohorts, NDUFAF4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated NDUFAF4 data layer compared with 3 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher NDUFAF4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NDUFAF4 expression acts as an unfavorable survival marker, although some lineages such as READ and THCA show a favorable association.

ESCA, LIHC, and BRCA are the cancer types where NDUFAF4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Quartile	II,III,IV	0.525	0.835	<.001	85	view →
LIHC	DFS	Tertile	All	0.214	0.473	<.001	68	view →
BRCA	OS	Tertile	All	0.541	0.716	.003	40	view →
LUAD	DFS	Tertile	III,IV	0.295	0.705	<.001	40	view →
HNSC	DFS	Tertile	All	0.230	0.411	<.001	39	view →
READ	DFS	Tertile	All	0.906	0.577	.001	38	view →
UCEC	DFS	Median	All	0.783	0.889	<.001	34	view →
THCA	DFS	Tertile	All	0.973	0.630	<.001	32	view →
KIRP	OS	Quartile	All	0.855	0.981	.010	20	view →
SCLC	OS	Median	IV	0.219	0.729	.003	19	view →
SARC	OS	Tertile	All	0.369	0.610	.004	11	view →
KICH	DFS	Quartile	II,III,IV	0.435	0.913	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

NDUFAF4–ESCA (OS)

Open the ESCA breakdown →