NAT14

Across TCGA patient cohorts, NAT14 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAT14-associated genes across cancer lineages are IL17A, ZYXP1, and MIR4734. Each is linked with NAT14 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAT14-to-partner and partner-to-NAT14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL17A grouped by NAT14-low versus NAT14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAT14→partner) and Y-score (partner→NAT14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IL17A →	+0.218	+2.709	<.001	.006	3	1
UCEC	ZYXP1 →	+0.208	+4.069	.001	.008	3	1
UCEC	MIR4734 →	+0.373	+2.902	.004	.006	3	1
UCEC	MIR6857 →	+0.363	+3.358	.001	.006	3	1
UCEC	OR6Q1 →	+0.033	+4.069	.008	.008	3	1
UCEC	SPANXN3 →	+0.159	+3.316	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

IL17A by NAT14 expression — UCEC

Explore this box plot interactively →