NAT14

Across TCGA pan-cancer cohorts, NAT14 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated NAT14 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher NAT14 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NAT14 expression acts as an unfavorable survival marker, although some lineages such as ESCA and THYM show a favorable association.

MESO, ACC, and KIRC are the cancer types where NAT14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.420	0.665	<.001	133	view →
ACC	DFS	Median	All	0.346	0.799	<.001	112	view →
KIRC	DFS	Tertile	II,III,IV	0.421	0.660	<.001	90	view →
SKCM	DFS	Quartile	III,IV	0.092	0.609	<.001	49	view →
UCS	OS	Median	II,III,IV	0.441	0.758	.005	48	view →
LGG	DFS	Median	All	0.629	0.844	<.001	48	view →
ESCA	DFS	Quartile	II,III,IV	1.000	0.236	.006	26	view →
LIHC	OS	Quartile	II,III,IV	0.282	0.637	.001	25	view →
LUSC	DFS	Quartile	II,III,IV	0.592	0.818	.006	22	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	21	view →
SARC	OS	Median	All	0.367	0.616	.003	21	view →
CHOL	DFS	Quartile	All	0.201	0.710	.006	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

NAT14–MESO (OS)

Open the MESO breakdown →