NALCN

Across TCGA cell cohorts, NALCN mutation is significantly associated with the RNA expression of many other genes, with 537 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NALCN-associated genes across cancer lineages are OR6T1, HSCB, and CUEDC2. Each is linked with NALCN in more than 1 cancer types. Because this analysis shows association rather than direction, both NALCN-to-partner and partner-to-NALCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6T1 grouped by NALCN-low versus NALCN-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NALCN→partner) and Y-score (partner→NALCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR6T1 →	+0.021	+3.836	.006	.004	3	2
LARGE_INTESTINE	HSCB →	+0.503	+2.265	.002	.001	3	2
LARGE_INTESTINE	CUEDC2 →	+0.519	+3.386	.002	.001	3	2
LARGE_INTESTINE	HINT3 →	+0.699	+2.949	<.001	<.001	3	2
LARGE_INTESTINE	STXBP3 →	+0.507	+2.265	<.001	.001	3	2
LARGE_INTESTINE	TXNDC12 →	+0.442	+3.082	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 537 associations by consensus.

OR6T1 by NALCN expression — OESOPHAGUS

Explore this box plot interactively →