NALCN

Across TCGA pan-cancer cohorts, NALCN RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of NALCN’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NALCN RNA is repressed in tumor relative to normal tissue. In most cancer types NALCN is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, BRCA, and CHOL are the cancer types where NALCN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NALCN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−1.120	<.001	6	view →
BRCA	Female	II,III,IV	−0.598	<.001	6	view →
CHOL	Female	All	+1.646	<.001	3	view →
LUSC	All	All	−0.407	.004	3	view →
STAD	Male	II,III,IV	+0.355	.008	3	view →
BLCA	Male	All	−0.666	.036	2	view →
KIRP	Male	All	−0.301	.040	1	view →
LIHC	Male	All	−0.205	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

NALCN–THCA

Open the THCA breakdown →