NALCN

Across TCGA pan-cancer cohorts, NALCN RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NALCN data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher NALCN RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NALCN expression acts as an unfavorable survival marker, although some lineages such as LGG and ESCA show a favorable association.

BLCA, MESO, and HNSC are the cancer types where NALCN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Quartile	All	0.385	0.729	.003	69	view →
MESO	DFS	Tertile	All	0.274	0.514	.001	61	view →
HNSC	OS	Tertile	All	0.274	0.590	<.001	60	view →
LGG	DFS	Median	All	0.832	0.636	<.001	51	view →
KIRP	OS	Tertile	II,III,IV	0.711	0.968	.001	40	view →
LUSC	DFS	Median	II,III,IV	0.256	0.500	<.001	38	view →
UVM	OS	Median	III,IV	0.209	0.836	<.001	30	view →
CESC	DFS	Tertile	All	0.725	0.878	<.001	26	view →
ESCA	OS	Quartile	III,IV	0.734	0.321	.004	25	view →
SARC	DFS	Quartile	All	0.504	0.738	.001	21	view →
COAD	DFS	Median	All	0.356	0.628	.004	19	view →
STAD	OS	Quartile	II,III,IV	0.235	0.538	.022	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NALCN–BLCA (OS)

Open the BLCA breakdown →