MTX3

Across TCGA patient cohorts, MTX3 mutation is significantly associated with the RNA expression of many other genes, with 2,513 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTX3-associated genes across cancer lineages are UBE2V1P14, RNA5SP198, and RAB5CP2. Each is linked with MTX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTX3-to-partner and partner-to-MTX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2V1P14 grouped by MTX3-low versus MTX3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTX3→partner) and Y-score (partner→MTX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	UBE2V1P14 →	+0.089	+7.640	<.001	.009	3	2
UCEC	RNA5SP198 →	+0.378	+2.714	<.001	.004	3	2
UCEC	RAB5CP2 →	+0.255	+2.291	<.001	.001	3	2
UCEC	RNA5SP422 →	+0.530	+1.893	.007	.008	3	2
UCEC	HSBP1P1 →	+0.316	+1.891	.001	.004	3	2
SKCM	CHCHD3P1 →	+0.198	+4.188	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,513 associations by consensus.

UBE2V1P14 by MTX3 expression — BLCA

Explore this box plot interactively →