MTX3

Across TCGA pan-cancer cohorts, MTX3 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of MTX3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MTX3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MTX3 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where MTX3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTX3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.915	<.001	11	view →
LIHC	Female	II,III,IV	+0.991	<.001	8	view →
THCA	All	II,III,IV	−0.480	<.001	8	view →
CHOL	Male	All	+1.685	<.001	5	view →
LUSC	Male	II,III,IV	+0.637	<.001	4	view →
READ	All	III,IV	+1.000	.028	2	view →
UCEC	All	All	−0.656	.001	2	view →
KIRP	Male	All	−0.430	.002	2	view →
LUAD	Male	All	+0.401	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

MTX3–HNSC

Open the HNSC breakdown →