MTX3

Across TCGA pan-cancer cohorts, MTX3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated MTX3 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher MTX3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MTX3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

OV, HNSC, and STAD are the cancer types where MTX3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Quartile	All	0.262	0.421	.002	62	view →
HNSC	DFS	Median	IV	0.664	0.487	.004	56	view →
STAD	DFS	Quartile	III,IV	0.354	0.638	.005	46	view →
KIRP	DFS	Median	IV	0.039	0.623	.001	44	view →
LGG	OS	Median	All	0.363	0.500	<.001	42	view →
UVM	DFS	Quartile	III,IV	0.232	0.801	.007	39	view →
KIRC	OS	Tertile	All	0.850	0.764	.015	33	view →
LIHC	OS	Quartile	All	0.601	0.832	.001	25	view →
SKCM	OS	Median	All	0.382	0.288	.004	23	view →
ESCA	DFS	Median	All	0.222	0.392	.018	11	view →
LUSC	OS	Median	II,III,IV	0.797	0.649	.005	11	view →
GBM	DFS	Tertile	All	0.411	0.199	.011	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

MTX3–OV (OS)

Open the OV breakdown →