Q-omics provides the consensus-scored MTHFD2P3 profile across patient tissues and cancer cell-line models. MTHFD2P3 expression is associated with patient survival in 9 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, MTHFD2P3 is differentially expressed in 1, with the highest sampling consensus in HNSC. Additionally, MTHFD2P3 RNA expression shows 5,874 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight ACC, HNSC, and STAD as cancer lineages where MTHFD2P3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MTHFD2P3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MTHFD2P3 survival associations across molecular data types. MTHFD2P3 RNA expression shows survival associations in the most cancer types (9). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MTHFD2P3 RNA expression–survival associations across cancer types. High MTHFD2P3 expression shows unfavorable associations in ACC, THCA, LUSC, HNSC, DLBC and LUAD. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for MTHFD2P3 RNA expression.
This table summarizes MTHFD2P3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for MTHFD2P3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MTHFD2P3 shows higher tumor expression in HNSC. The HNSC box plot shows higher MTHFD2P3 RNA expression in tumor versus normal tissue (log2 FC = +0.055, t-test p = .048).
This table shows molecular features associated with MTHFD2P3 in patient tissues and cancer cell lines. In patient samples, MTHFD2P3 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
