MTHFD2P3

Across TCGA pan-cancer cohorts, MTHFD2P3 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated MTHFD2P3 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MTHFD2P3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MTHFD2P3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ACC, THCA, and LUSC are the cancer types where MTHFD2P3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.057	0.667	<.001	45	view →
THCA	DFS	Tertile	III,IV	0.113	0.747	<.001	42	view →
LUSC	DFS	Tertile	III,IV	0.045	0.790	<.001	39	view →
HNSC	OS	Tertile	II,III,IV	0.183	0.605	.010	36	view →
DLBC	OS	Tertile	All	0.179	0.909	.002	30	view →
LUAD	DFS	Tertile	IV	0.223	0.710	.043	18	view →
UCEC	DFS	Tertile	II,III,IV	0.905	0.308	.026	12	view →
UVM	DFS	Tertile	III,IV	0.079	0.635	.021	9	view →
SKCM	OS	Tertile	II,III,IV	0.511	0.751	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

MTHFD2P3–ACC (DFS)

Open the ACC breakdown →